ISSN: 2148-8274 / E-ISSN: 2587-0084
, Türk Üreme Tıbbı ve Cerrahisi
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Turkish Journal of Reproductive Medicine and Surgery

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Açıklanamayan İnfertil ve Fertil Kadınlarda Serum Leptin Düzeylerinin Karşılaştırılması
Comparison of the Serum Leptin Levels Among the Fertile Women and Women With Unexplained Infertilites
Received Date : 15 Dec 2021
Accepted Date : 12 Jan 2022
Available Online : 28 Jan 2022
Doi: 10.24074/tjrms.2020-80415 - Makale Dili: TR
TJRMS. 2021;5(3):88-93
ÖZET
Amaç: İnfertilite ile leptinin dolaylı ilişkisinin olup olmadığını değerlendirerek fertiliteye katkı sağlamaktır. Gereç veYöntemler: Çalışmamız Aralık 2018 ile Mayıs 2019 tarihleri arasında, hastanemiz İnfertilite/IVF Kliniği’ne başvuran açıklanamayan infertilite tanısı konmuş 24 hasta ile kontrol grubu olarak Jinekoloji Kliniği’ne diğer benign sebeplerle başvuran 24 fertil kadın ile gerçekleştirildi. Reproduktif çağdaki bu kadınların vücut kitle indeksleri ölçüldü; 12’si obez (VKİ≥25 kg/m²), 12’si nonobez (VKİ: 18.5-24.9 kg/m2) olmak üzere 24 infertil hasta ve kontrol grubunda ise 12’si obez (VKİ ≥25 kg/m2), 12’si nonobez (VKİ: 18.5-24.9 kg/m2) olmak üzere 24 fertil kadın çalışmaya dâhil edildi. Tüm grubun (n=48) foliküler faz sırasında (âdetin 2/3. günü) en az 8 saatlik açlık sonrasında kandaki leptin hormon değerleri ölçülerek kaydedildi. Bulgular: Çalışmamıza dâhil edilen infertil grubun yaş ortalaması 27±5 iken, kontrol grubun yaş ortalaması 34±6 idi. Ortalama VKİ, infertil grupta 25,26±5,33 iken, kontrol grupta 26,16±5,26 idi. İnfertil grupta (n=24), leptin düzeyi ortalaması 1,015±0,284 ng/ml olarak değerlendirilirken, fertil grupta (n=24) leptin düzeyi ortalaması 0,937±0,150 ng/ml şeklinde ölçüldü. Çalışma ve kontrol grubunda bulunan obez kadınlarda (n=24) leptin düzeyi ortalaması 0,961±0,154 ng/ml olarak değerlendirilirken, yine her iki çalışma ve kontrol grubuna ait non-obez kadınlarda (n=24) ise 0,991±0,287 ng/ml olarak ölçüldü. Sonuç: Çalışmamızda açıklanamayan infertil tanısı olan hastalarda ve fertil kadınlarda, serum leptin düzeyleri açısından istatistiksel bir fark izlenmedi. Obez ve non-obez olmaları bulguları değiştirmemiş olup bu alt grupların leptin düzeyleri arasında da istatistiksel olarak bir fark bulunamamıştır.
ABSTRACT
Objective: Our aim is to contribute to fertility by evaluating whether there is an indirect relationship between infertility and leptin. Material and Methods: Our study was conducted between December 2018 and May 2019, with 24 patients who were diagnosed with unexplained infertility and 24 fertile women who were admitted to the Gynecology Clinic for other benign reasons, as a control group. Body mass indexes of these reproductive age women were measured and according to their fertility and body mass index; obese (BMI ≥25 kg/m²) 12 patients, non-obese (BMI: 18.5-24.9 kg/m²) 12 patients, 24 infertile women were included in the study. In the control group, obese (BMI ≥25 kg/m²) 12 patients, non-obese (BMI: 18.5-24.9 kg/m²) 12 patients, was formed by 24 fertil women. During the follicular phase (day 2/3 of menstruation) of the whole group (n=48), blood leptin hormone levels were measured at least 8 hours after fasting. Results: While the mean age of the infertile group included in our study was 27±5, the mean age of the control group was 34±6. The mean BMI was 25.26±5.33 in the infertile group and 26.16±5.26 in the control group. In the infertile group (n=24), the mean leptin level was 1.015±0.284 ng/ml, while in the fertile group (n=24) the mean leptin level was 0.937±0.150 ng/ml. The mean leptin level in the study and control groups was 0.961±0.154 ng/ml in obese women (n=24), while it was 0.991±0.287 ng/ml in non-obese women (n=24) in both study and control groups. Conclusion:In our study, there was no statistically significant difference in serum leptin levels in unexplained infertile patients and fertile women. Obese and non-obese did not change the findings and there was no statistically significant difference between the leptin levels of these groups.
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