ISSN: 2148-8274 / E-ISSN: 2587-0084
, Türk Üreme Tıbbı ve Cerrahisi
Dergisi

Turkish Journal of Reproductive Medicine and Surgery

Dernek Sitesi
Kayıtlı İndexler
OLGU SUNUMLARI

Dikkat: Kronik Renal Yetmezliği Olan Kadınlarda Ektopik Gebelik Tedavisinde Tek, Düşük Doz Metotreksat Bile Ciddi Yan Etkiler Yapabilir: Bir Olgu Sunumu
Caution: Even in A Single-Low Dose Methotrexate for Treatment of Ectopic Pregnancy Could Have Severe Adverse Effects in Women with Chronic Renal Insufficiency: A Case Report
Received Date : 14 Dec 2020
Accepted Date : 06 Jan 2021
Available Online : 25 Aug 2021
Doi: 10.24074/tjrms.2020-80598 - Makale Dili: EN
TJRMS. 2021;5(2):66-9
ÖZET
Bu olgu sunumunda, kronik renal yetmezlik nedeniyle hemodiyaliz olan ve ektopik gebelik için tek, düşük doz metotreksat (Mtx) uygulaması sonrası şiddetli oral mukozit, cilt döküntüsü ve kemik iliği supresyonu geliştiren bir hasta bildirilmiştir. Böbrek yetmezliği olan hastalarda düşük dozda bile olsa Mtx’den kaçınılmalıdır
ABSTRACT
In this case report, a patient on hemodialysis due to chronic renal insufficiency and developed severe oral mucositis, skin rash and bone marrow suppression after being treated with single low-dose methotrexate (Mtx) for ectopic pregnancy was reported. Mtx even in low dose should be avoided in patients with renal insufficiency.
SITE.TEXT.RESOURCES
  1. Barnhart K, Coutifaris C, Esposito M. The pharmacology of methotrexate. Expert Opin Pharmacother. 2001;2(3):409-17. [Crossref] 
  2. Cheung KK, Chow KM, Szeto CC, Tai MH, Kwan BC, Li PK. Fatal pancytopenia in a hemodialysis patient after treatment with low-dose methotrexate. J Clin Rheumatol. 2009;15(4):177-80. [Crossref] 
  3. Spencer K, Enofe O, Cowans NJ, Stamatopoulou A. Is maternal renal disease a cause of elevated free β‐hCG in first trimester aneuploidy screening? Prenat Diagn 2009;29(11):1045-9. [Crossref] 
  4. Willner N, Storch S, Tadmor T, Schiff E. Almost a tragedy: severe methotrexate toxicity in a hemodialysis patient treated for ectopic pregnancy. Eur J Clin Pharmacol. 2014;70(3):261-3. [Crossref] 
  5. Kelly H, Harvey D, Moll S. A cautionary tale: fatal outcome of methotrexate therapy given for management of ectopic pregnancy. Obstet Gynecol. 2006;107(2 Pt 2):439-41.Erratum in: Obstet Gynecol. 2006;107(5): 1171. [Crossref] 
  6. Murashima M, Adamski J, Milone MC, Shaw L, Tsai DE, Bloom RD. Methotrexate Clearance by High-Flux Hemodialysis and Peritoneal Dialysis: A Case Report. Am J Kidney Dis. 2009;53:871-4 [Crossref] 
  7. Benachi A, Dreux S, Kaddioui-Maalej S,et al. Down syndrome maternal serum screening in patients with renal disease. Am J Obstet Gynecol. 2010;203(1):60.e1-4. [Crossref]