Amaç: Bu çalışmanın amacı, benign sebeplerle total abdominal histerektomi (TAH) yapılan hastalarda, operasyon sırasında bilateral salpenjektomi eklemenin over rezervi üzerindeki etkisini serum anti-Müllerian hormon (AMH) seviyeleri ile incelemektir. Gereç ve Yöntemler: Çalışma kapsamında, benign nedenlerden dolayı total abdominal histerektomi planlanan 40-45 yaş arası 29 premenopozal hasta seçildi. Hastalar, yalnızca total abdominal histerektomi yapılanlar (TAH, n=15) ve histerektomi ile birlikte bilateral salpenjektomi uygulananlar (TAH+BS, n=14) olarak iki gruba ayrıldı. Her iki grupta preoperatif, postoperatif 2. gün ve 1. ayda serum AMH seviyeleri ölçüldü. Ek olarak, menstrüel döngünün 3. gününde FSH, LH ve E2 düzeyleri değerlendirildi. Bulgular: Grupların yaş ortalamaları (TAH: 43.13±1.68, TAH+BS: 42.85±1.56, p=0.447) ve VKİ değerleri (TAH: 29.22±4.03, TAH+BS: 27.35±5.60, p=0.280) benzerdi. Preoperatif AMH düzeyleri TAH grubunda 1.14±0.78 ng/mL, TAH+BS grubunda 1.16±0.58 ng/mL olarak kaydedildi (p=0.906). Her iki grupta da postoperatif dönemde AMH değerlerinde düşüş izlendi. Postoperatif 2. gün (TAH: 0.79±0.13, TAH+BS: 0.75±0.21, p=0.691) ve 1. ay (TAH: 0.94±0.78, TAH+BS: 0.92±0.58, p=0.377) ölçümlerinde, gruplar arası anlamlı bir fark saptanmadı. Sonuç: Histerektomi sırasında bilateral salpenjektomi eklenmesinin over rezervine ek bir olumsuz etkisi gözlenmemiştir. Bu durum, over kanseri riskini azaltmak amacıyla histerektomi esnasında bilateral salpenjektominin güvenle uygulanabileceğini göstermektedir.

Objective: The goal of this research was to explore how intraoperative bilateral salpingectomy impacts ovarian reserve in individuals undergoing hysterectomy (TAHS due, to non cancerous reasons. Serum anti-Müllerian hormone (AMH) levels were used as the primary biomarker to evaluate ovarian reserve. Material and Methods: We selected 29 premenopausal patients aged 40-45 years who were scheduled for total abdominal hysterectomy for benign indications. Participants were allocated into two groups based on surgical preference: total abdominal hysterectomy only (TAH, n=15) and total abdominal hysterectomy with bilateral salpingectomy (TAH+BS, n=14). Serum AMH levels were measured in both groups preoperatively, on postoperative day 2 and at 1 month postoperatively. In addition, follicle-stimulating hormone (FSH), luteinizing hormone (LH), and estradiol (E2) levels were evaluated on day 3 of the menstrual cycle. Results: The mean age (TAH: 43.13±1.68, TAH+BS: 42.85±1.56, p=0.447) and BMI values (TAH: 29.22±4.03, TAH+BS: 27.35±5.60, p=0.280) of the groups were similar. Preoperative AMH levels were 1.14±0.78 ng/mL in the TAH group and 1.16±0.58 ng/mL in the TAH+BS group (p=0.906). Both groups demonstrated a significant decrease in AMH values during the postoperative period, with the nadir occurring on postoperative day 2. There was no significant difference between the groups in postoperative day 2 (TAH: 0.79±0.13, TAH+BS: 0.75±0.21, p=0.691) and 1-month (TAH: 0.94±0.78, TAH+BS: 0.92±0.58, p=0.377) measurements. Conclusion: The addition of bilateral salpingectomy during hysterectomy had no additional negative effect on ovarian reserve compared to hysterectomy alone. This indicates that having both fallopian tubes removed can be done safely at the time, as a hysterectomy to lower the chances of developing cancer.

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