ISSN: 2148-8274 / E-ISSN: 2587-0084
, Türk Üreme Tıbbı ve Cerrahisi
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Turkish Journal of Reproductive Medicine and Surgery

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Sekonder İnfertil Hastalarda İstmosel Tanısında Solid Embriyo Transfer Kateteri Kullanarak Salin İnfüzyon Sonografisinin Uygulanabilirliği ve Etkinliği
The Applicability and Effectiveness of Saline Infusion Sonography Using Solid Embryo Transfer Catheter in the Diagnosis of Isthmocele in Patients with Secondary Infertility
Received Date : 13 Sep 2022
Accepted Date : 13 Dec 2022
Available Online : 15 Dec 2022
Doi: 10.24074/tjrms.2022-93348 - Makale Dili: EN
TJRMS. 2022;6(2):162-6
ÖZET
Amaç: İstmosel, sekonder infertilitesi olan hastalarda etiyolojik bir faktör olarak suçlanmıştır. Sekonder infertilitesi olan hastalarda solid embriyo transfer kateteri kullanılarak salin infüzyon sonografisinin tanısal etkisini araştırmayı amaçladık. Gereç ve Yöntem: Çalışmaya Ankara Üniversitesi Üreme Sağlığı Teşhis ve Tedavi Merkezi'ne infertilite değerlendirmesi için başvuran ve standart transvajinal ultrasonografik değerlendirmede istmosel şüphesi bulunan 16 hasta alındı. Daha sonra tüm hastalar, teşhisi doğrulamak ve istmoselin taban genişliğini ve alanını ve doğrulanırsa myometriyal kalınlığı ölçmek için salin infüzyonu sonografik değerlendirmesine tabi tutuldu. Bulgular: Hastaların yaş ortalaması 37.7±3.7, ortalama gravida 2.7±1.4 ve ortalama parite 2.0±0.8 idi. Ortalama işlem süresi 4,1±1,1dk idi. Hastalardan 13'üne daha önce bir sezaryen, üçünde iki sezaryen doğum hikayesi mevcuttu. Ortalama sekonder infertilite süresi 19.18 aydı. İnfertilite dışında 10 hastada (%62.5) intermenstrüel kanama, sekiz hastada (%50) uzamış menstrual kanama ve altı hastada (%37.5) mukus akıntısı mevcuttu. Ölçülen ortalama istmosel taban genişliği 5.6±1.6 ve 10.1±2.4 mm (p<0.001), istmosel alanı 21.2±5.2'ye karşılık 38.7±10.2 mm2 (p<0.001) ve rezidüel myometrial kalınlık 5.4±2.5 mm ve 4.8 idi. Sırasıyla salin infüzyon sonografisinden önce ve sonra 5.4±2.5mm and 4.8±2.1 mm (p=0.49) idi. Sonuç: Özellikle rutin transvajinal ultrason muayenesi sırasında şüpheli tanı konulan hastalarda istmosel konturları, alanı ve rezidüel myometrial kalınlık salin infüzyon sonografi ile daha net olarak gösterilebilir. Embriyo transfer kateteri kullanılarak salin infüzyon sonografisi, istmosel teşhisine ve sekonder infertiliteye sahip hastalarda optimal tedavi yaklaşımını uyarlamaya yardımcı olabilecek güvenli ve kolay bir prosedürdür.
ABSTRACT
Objectives: Isthmocele has been implicated as a causal factor in patients with secondary infertility. We aimed to investigate the diagnostic effect of saline infusion sonography using solid embryo transfer catheter in patients suffering from secondary infertility. Materials and Methods: Sixteen patients who applied for infertility evaluation at the Center for Human Reproduction and Infertility of Ankara University and were suspected to have isthmocele on standard vaginal ultrasonographic evaluation were enrolled in the study. All patients were then subjected to saline infusion sonographic evaluation to confirm the diagnosis and measure the base width and area of the isthmocele, and myometrial thickness if confirmed. Results: The mean age of the patients was 37.7±3.7, mean gravida was 2.7±1.4, and mean parity was 2.0±0.8. The mean procedure time was 4.1±1,1min. Among the patients, 13 underwent one previous cesarean section, and three experienced two cesarean births. The mean duration of secondary infertility was 19.18 months. Apart from infertility, 10 patients (62.5%) suffered from intermenstrual bleeding, eight (50%) suffered from prolonged bleeding, and six suffered from mucous discharge (%37.5). The mean measured isthmocele base width was 5.6±1.6 and 10.1±2.4 mm (p<0.001), isthmocele area was 21.2±5.2 vs. 38.7±10.2 mm2 (p<0.001), and residual myometrial thickness was 5.4±2.5mm and 4.8±2.1mm (p=0.49) before and following saline infusion sonography respectively. Conclusions: The contours and area of isthmocele and residual myometrial thickness can be more clearly depicted by saline infusion sonography, especially in patients with a suspicious diagnosis during routine transvaginal ultrasound examination. Saline infusion sonography using an embryo transfer catheter is a safe and easy procedure that may aid in the diagnosis of isthmocele and in tailoring the optimal treatment approach in patients suffering from secondary infertility.
REFERANSLAR
  1. Betrán AP, Ye J, Moller AB, Zhang J, Gülmezoglu AM, Torloni MR. The Increasing Trend in Caesarean Section Rates: Global, Regional and National Estimates: 1990-2014. PLoS One. 2016;11(2):e0148343. [Crossref]  [PubMed]  [PMC] 
  2. Poidevin LO. The value of hysterography in the prediction of cesarean section wound defects. Am J Obstet Gynecol. 1961;81:67-71. [Crossref]  [PubMed] 
  3. Monteagudo A, Carreno C, Timor-Tritsch IE. Saline infusion sonohysterography in nonpregnant women with previous cesarean delivery: the "niche" in the scar. J Ultrasound Med. 2001;20(10):1105-15. [Crossref]  [PubMed] 
  4. Mc Gowan S, Goumalatsou C, Kent A. Fantastic niches and where to find them: the current diagnosis and management of uterine niche. Facts Views Vis Obgyn. 2022;14(1):37-47. [Crossref]  [PubMed]  [PMC] 
  5. Jordans IPM, de Leeuw RA, Stegwee SI, Amso NN, Barri-Soldevila PN, van den Bosch T, et al. Sonographic examination of uterine niche in non-pregnant women: a modified Delphi procedure. Ultrasound Obstet Gynecol. 2019;53(1):107-15. [Crossref]  [PubMed]  [PMC] 
  6. Tower AM, Frishman GN. Cesarean scar defects: an underrecognized cause of abnormal uterine bleeding and other gynecologic complications. J Minim Invasive Gynecol. 2013;20(5):562-72. [Crossref]  [PubMed] 
  7. Bij de Vaate AJ, van der Voet LF, Naji O, Witmer M, Veersema S, Brölmann HA, et al. Prevalence, potential risk factors for development and symptoms related to the presence of uterine niches following Cesarean section: systematic review. Ultrasound Obstet Gynecol. 2014;43(4):372-82. [Crossref]  [PubMed] 
  8. Ofili-Yebovi D, Ben-Nagi J, Sawyer E, Yazbek J, Lee C, Gonzalez J, et al. Deficient lower-segment Cesarean section scars: prevalence and risk factors. Ultrasound Obstet Gynecol. 2008;31(1):72-7. [Crossref]  [PubMed] 
  9. van der Voet LF, Vervoort AJ, Veersema S, BijdeVaate AJ, Brölmann HA, Huirne JA. Minimally invasive therapy for gynaecological symptoms related to a niche in the caesarean scar: a systematic review. Bjog. 2014;121(2):145-56. [Crossref]  [PubMed] 
  10. van der Voet LF, Jordans IPM, Brölmann HAM, Veersema S, Huirne JAF. Changes in the Uterine Scar during the First Year after a Caesarean Section: A Prospective Longitudinal Study. Gynecol Obstet Invest. 2018;83(2):164-70. [Crossref]  [PubMed] 
  11. Vikhareva Osser O, Valentin L. Risk factors for incomplete healing of the uterine incision after caesarean section. Bjog. 2010;117(9):1119-26. [Crossref]  [PubMed] 
  12. Wang CB, Chiu WW, Lee CY, Sun YL, Lin YH, Tseng CJ. Cesarean scar defect: correlation between Cesarean section number, defect size, clinical symptoms and uterine position. Ultrasound Obstet Gynecol. 2009;34(1):85-9. [Crossref]  [PubMed] 
  13. Vissers J, Sluckin TC, van Driel-Delprat CCR, Schats R, Groot CJM, Lambalk CB, et al. Reduced pregnancy and live birth rates after in vitro fertilization in women with previous Caesarean section: a retrospective cohort study. Hum Reprod. 2020;35(3):595-604. [Crossref]  [PubMed]  [PMC] 
  14. Lawrenz B, Melado L, Garrido N, Coughlan C, Markova D, Fatemi H. Isthmocele and ovarian stimulation for IVF: considerations for a reproductive medicine specialist. Hum Reprod. 2020;35(1):89-99. [Crossref]  [PubMed] 
  15. Morris H. Surgical pathology of the lower uterine segment caesarean section scar: is the scar a source of clinical symptoms? International journal of gynecological pathology: official journal of the International Society of Gynecological Pathologists. 1995;14(1):16-20. [Crossref]  [PubMed] 
  16. Karpathiou G, Chauleur C, Dridi M, Baillard P, Corsini T, Dumollard JM, et al. Histologic Findings of Uterine Niches. Am J Clin Pathol. 2020;154(5):645-55. [Crossref]  [PubMed] 
  17. Gubbini G, Casadio P, Marra E. Resectoscopic correction of the "isthmocele" in women with postmenstrual abnormal uterine bleeding and secondary infertility. J Minim Invasive Gynecol. 2008;15(2):172-5. [Crossref]  [PubMed]